![]() Recent studies suggest that several biomarkers evaluated during routine blood tests upon admission may be independent predictors of poor clinical outcomes in patients with STEMI. Recent guidelines recommend using risk scores, for early risk assessment and adjustment, such as the TIMI (Thrombolysis in Myocardial Infarction) for STEMI, TIMI for NSTEMI, and GRACE (Global Registry of Acute Coronary Events) for both types of myocardial infarction (MI). Several risk stratification scores have been designed to predict mortality or complications in patients with non-ST-segment elevation myocardial infarction (NSTEMI) and ST-segment elevation myocardial infarction (STEMI). The addition of HLI, dysglycemia, anemia, and high NLR to the TIMI risk score may be useful for very early risk stratification in patients with STEMI receiving primary PCI. The best cutoff value of NLR for the prediction of 1-year mortality was 4.3 (sensitivity, 67% specificity, 65%). The effect of adding biomarkers to the TIMI risk score on its discriminative ability was assessed using c-statistic, net reclassification improvement (NRI), and integrated discrimination improvement (IDI). HLI and dysglycemia were defined as serum transaminase > twice the normal upper limit and glucose 250 mg/dL, respectively. MethodsĪ total of 1057 patients with STEMI undergoing primary percutaneous coronary intervention (PCI) between 20 were retrospectively enrolled from 4-regional hospitals. We investigated whether adding information obtained from routine blood tests including hypoxic liver injury (HLI), dysglycemia, anemia, and high neutrophil to lymphocyte ratio (NLR) could improve the prognostic performance of the TIMI risk score for the prediction of 1-year mortality. Patients with TIMI score > 4 were more likely to have significant three vessel CAD and LMS versus those with TIMI risk score 4 should be referred for early invasive coronary evaluation to derive clinical benefit.Several biomarkers have been proposed as independent predictors of poor outcomes in ST-segment elevation myocardial infarction (STEMI). The extent of CAD was evaluated on angiography and significant CAD was defined as ≥ 70% stenosis in any one of the three major epicardial vessels and ≥50% in LMS.Results : Among 100 patients with UA/NSTEMI, 82% of patients have one or more risk factors and only 18%of patients lacked any of 4 conventional risk factors.Smoking is the most common risk factor in male patients while diabetes mellitus and dyslipidemia are common among female patients, and all these results are statistically significant.There were 64 % patients with TIMI score 4 (high TIMI risk score). The TIMI risk score was stratified on seven standard variables. Extensive epidemiological research has established cigarette smoking, diabetes, hyperlipidemia, and hypertension as independent risk factors for CADObjective: To determine the prevalence of the 4 conventional risk factors(cigarette smoking, diabetes, hyperlipidemia, and hypertension) among patients with CAD and to determine the correlation of Thrombolysis in Myocardial Infarction (TIMI) risk score with the extent of coronary artery disease (CAD) in patients with unstable angina /non ST elevation myocardial infarction (UA/NSTEMI).Methods: We conducted a descriptive study among 100 patients admitted with UA/NSTEMI to three major cardiac centers in Iraq: Iraqi Centre for Heart Disease ,Ibn- Al-Bitar Hospital for cardiac surgery and Al -Nasyria Cardiac Centre from January 2010 to January 2o11.Frequency of each conventional risk factors and number of conventional risk factors present among patients with CAD, compared between men and women and by age are estimated at study entry. Unstable angina, Thrombolysis in Myocardial Infarction score, risk factors Abstractīackground: Appreciation of the crucial role of risk factors in the development of coronary artery disease (CAD) is one of the most significant advances in the understanding of this important disease.
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